
The cause of the crash wasn't immediately known.
"From the United States military, we have received an initial report that engine trouble might be the cause", he said. "Prayers for all involved".
In Washington, the White House said President Donald Trump had been briefed on the crash.
The aircraft was headed to the USS Ronald Reagan aircraft carrier, which is deployed to the Philippine Sea.
The C2-A "Greyhound" crashed about 500 nautical miles southeast of Okinawa Wednesday afternoon, on its way to the USS Ronald Reagan from Marine Corps Air Station Iwakuni.
The Navy says in a tweet that the eight are on board the USS Ronald Reagan aircraft carrier.
The C-2 is a twin-engine cargo plane created to transport people and supplies to and from aircraft carriers.
The Defense Ministry says it had no information on their condition. But Japanese Defense Minister Itsunori Onodera said, "I have been informed from the USA military that engine trouble may have caused (the crash)", per CNN. The Reagan is home-ported at the US naval base in Yokosuka, Kanagawa Prefecture.
Three people are still missing after a U.S. Navy plane crashed in the Philippine Sea en route to the aircraft carrier USS Ronald Reagan.
The Japan-based 7th Fleet says in a statement that the search and rescue operation has been launched from the carrier.
It was operating in the Philippine Sea when the crash happened at 2.45pm local time (approximately 5.45am GMT).
Search and rescue efforts continue for the other three people onboard the aircraft when it went down.
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